HarvardX: Fundamentals of Neuroscience, Part 2: Neurons and Networks course Syllabus

This course explores the fundamental mechanisms of neuronal communication and network dynamics, building on core concepts from neuroscience. Over approximately 12–16 weeks, learners will engage with scientifically rigorous content covering how neurons generate electrical signals, communicate at synapses, form functional circuits, and adapt through plasticity. Each module integrates theoretical knowledge with experimental approaches used in modern neuroscience research. The course is designed for learners seeking a strong academic foundation and requires consistent engagement of 6–8 hours per week.

Module 1: Electrical Properties of Neurons

Estimated time: 20 hours

• Understand membrane potential and ion channels
• Learn how action potentials are generated
• Explore voltage-gated channels
• Analyze signal propagation along axons

Module 2: Synaptic Transmission

Estimated time: 20 hours

• Study chemical and electrical synapses
• Understand neurotransmitter release mechanisms
• Explore postsynaptic responses
• Analyze excitatory and inhibitory balance

Module 3: Neural Circuits and Networks

Estimated time: 20 hours

• Understand how neurons form functional circuits
• Explore network integration and modulation
• Study neural coding principles
• Analyze sensory and motor pathways

Module 4: Plasticity and Experimental Methods

Estimated time: 20 hours

• Explore synaptic plasticity mechanisms
• Understand learning-related neural changes
• Study electrophysiology techniques
• Interpret neural recording data

Module 5: Integration and Application

Estimated time: 15 hours

• Synthesize knowledge of neuronal signaling and networks
• Apply concepts to real-world neuroscience scenarios
• Examine case studies in brain function and dysfunction

Module 6: Final Project

Estimated time: 15 hours

• Design a hypothetical experiment to study neural activity
• Apply appropriate experimental methods (e.g., electrophysiology or imaging)
• Present findings in a structured scientific format

Prerequisites

• Completion of HarvardX Fundamentals of Neuroscience Part 1
• Basic understanding of cell biology and physiology
• Familiarity with fundamental scientific reasoning and data interpretation

What You'll Be Able to Do After

• Explain how neurons generate and propagate electrical signals
• Describe the mechanisms of synaptic transmission and neural communication
• Analyze how neural circuits process information
• Apply experimental methods to study brain activity
• Prepare for advanced studies or careers in neuroscience and related fields